The Tomás Estrada Palma Collection contains materials from a scrapbook donated by the great-grandson of TEP, Tomás Douglas Estrada Palma III. Items that were preserved in the scrapbook include photographs, letters, personal documents, and newspaper clippings. They document primarily the Tomás Andrés Estrada Palma II branch of the Estrada Palma family tree, including some materials related to his wife, Helen Douglas Browne, and her family.

Correspondence includes letters written by TEP, TEP II and other members of the Estrada Palma family. Clippings largely cover the 1906 resignation of TEP from the Cuban presidency and the consequent US military occupation, TEP's death in 1908, as well as events honoring TEP in the years after his death. Also amongst the clippings are articles relating to TEP II's marriage to Helen Douglas Browne in 1910. Other items include documents such as TEP II's report card, marriage certificate, and passport. There are also photographs of TEP, TEP II, and TEP III, as well as photos of other members of the family such as Genoveva Guardiola de Estrada Palma, Candelaria "Candita" Estrada Palma, and Helen (Douglas Browne) Estrada Palma. Of special interest is a photograph of the presidential convoy that traveled with TEP from Bayamo to Havana for his inauguration in 1902 and photographs of the Presidential Palace in Havana taken during TEP's presidency.

Included in this collection is the citizenship certificate of José Guimunde y Martínez, which was signed by TEP. This document was donated by Mirtha Alberto in August 2000 and added to the Tomás Estrada Palma Collection at that time.