The Frost Museum of Science had originally opened in 1950 under the name the Junior Museum of Miami and has since underwent several renovations and relocations. It had also been renamed in 1952 as the Museum of Science and Natural History and once again renamed in 2011 after Phillip and Patricia, two wealthy and influential Miami philanthropists who have donated and supported various educational institutes and museums throughout South Florida, including the University of Miami. In its current inception, the Frost Museum of Science is located in Downtown Miami's waterfront Museum Park and offers a variety of STEM (Science Technology Engineering and Math)-based exhibits, lectures, and shows. It is particularly well-known for hosting the show Star Gazers with Jack Horheimer (formerly Jack Horheimer: Star Hustlers and Jack Horheimer: Star Gazer).

This collection includes typescripts for the Star Gazers (Star Hustler) planetarium show, research files, exhibit files, exhibit prints, convention proceedings, pamphlets, historical news clippings, ephemera, periodicals, scrapbooks, photographs, event files, administrative records, and other archival documents pertaining to the Frost Museum of Science's day-to-day operations.

This collection contains records from the Bascom Palmer Eye Institute Department of Ophthalmology, administrative documents, development documents, materials from the Eye bank, Allied papers, Edward W. D. Norton's papers, general files, architectural designs and planning documents, papers from other notable faculty and administrators, newsletters, promotional materials, photographs, awards, plaques, ephemera, and audio-visual materials.