The Florence Brigham Papers consist of four boxes of material totalling two cubic feet of files. The Papers include research materials Brigham compiled from numerous primary and secondary sources including articles and books, diaries, notes and other materials. Brigham also conducted interviews with early Keys residents, including many employees of the Federal East Coast Railroad Company. Newspaper clippings dated 1935-69 detail local history, "pioneers," hurricanes and other topics. In addition to these records, the files include correspondence with a number ofarchives and libraries, and photostats of original documents and maps. Brigham also collected prints of Marathon dated 1906-1960.

The Papers include notes on Keys deer, birds, reptiles and other animals, as well as clippings and notes on schools, churches, fishing, libraries and other institutions and activities in the Keys. Historical material includes copies of early maps, records tracing the title of Keys lands, and materials documenting the construction of the "Overseas Railroad" and the development of Marathon.