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The papers document activities of J. M. Portuondo in capacity of a professor of Internal Medicine at the University of Havana, a writer and a faculty member of the University of Miami School of Medicine.  The materials include books, pamphlets, periodicals, clippings, circular letters, typescripts of anti-communist writings by Portuondo, reports, a poem by Portuondo, speeches by him, copies of his medical diplomas, a historical map of Havana, and photostats of a photograph and of a letter from José Martí to José Portuondo.

The papers consist primarily of facsimilies and copies of documents relating to colonial Cuba.