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Florence Brigham researched and collected materials on the Florida Keys and wrote articles on the history of Marathon and Key Vaca. While a student at the University of Miami, Brigham completed a History of Key Vaca, published in the Southern Florida Historical Association journals for 1957 and 1958. She presented a paper "They Chose Key Vaca," before the Association in 1957, and another of Brigham's articles later appeared in Tequesta magazine.

Brigade 2506 was the name given to a CIA-sponsored group of Cuban exiles formed in 1960 to attempt the military overthrow of the Cuban government headed by Fidel Castro. It carried out the abortive Bay of Pigs Invasion landings in Cuba on 17 April 1961.