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This collection brings together a variety of historical documents that are topically related to Latin America, including manuscripts, correspondence, and illustrations. The documents range from 1420 to 1994 in date, and originate from Mexico, New Granada, Panama, Peru, Colombia, Ecuador, and other parts of Latin America.

This collection contains research materials on Panama collection during Oscar De Soto's time working for the Department of State, including handwritten notes, negatives, medica clippings, transcripts, essays, photocopies of articles and publications, reports, and periodicals.