This collection contains various materials documenting the rich history of LGBTQ+ (lesbian, gay, bisexual, transgender, questioning, queer, intersex, pansexual, two-spirit (2S), and asexual) culture in Florida and its many decades of political and social activism. Included within are periodicals, ephemera, political tracts, general documents, and advertisements pertaining to the LGBTQ+ lifestyle and hailing from both earlier and contemporary eras. The contents of this collection will continue to grow as more materials are purchased and collected.

This collection features several posters documenting the AIDS awareness movement from the 80's to the present to educate people about the HIV/AIDS epidemic and prevent its spread in various countries of the world. Nations currently represented in the collection are Brazil, Germany, United States, and South Africa.